Survives conduced in different populations revealed that even a small affection of melasma in the facial area can lead to significant emotional and psychological affliction, that is why treating it appropriately is so important.

MeLine range of products developed in Innoaesthetics Laboratories, thanks to the join efforts of our R&D department and our medical department, offers an innovative therapeutic activity. Deep knowledge regarding the development and evolution of the melasma and how it affects to the different skin phototypes and to a specific area has allow our specialist to design products that treat these specific skin pigmentation problems in a safe and effective way.

Many scientific investigations have led us to find the ideal formula: a combination of active ingredients that acts on pre-synthesis of melanin, as well as on the direct activity (synthesis) and post-synthesis of tyrosinase controlling then the different stages that are involved in the deposit of melanin on the tissues and the constitution of a pigmented stain.

MeLine Caucasian Skin products are essentially addressed to the treatment of melasma in skin phototypes I – IV. The synergy of its actives allows: the inhibition of hormonal activity on the melanocyte, controlling the activity of free radicals, improving the condition of the epidermal tissue, chelation of the minerals that activate enzymatic activity, blocking tyrosinase activity, promoting epidermal renewal to remove the content of pigment in the cell.

The treatment protocol includes two homecare products that work in synergy and complement the professional treatment applied by the specialist. These two products will help to control the activity of melanin and the production of tyrosinase enzyme. They are essential to complete the treatment as they enhance its efficacy and prolong its effects.

Another aspect to consider when treating ethnic skins is the development of post-inflammatory hyperpigmentations in which the pigment (as it happens with affections of melasma) can be deposited only in the epidermis or in both, dermis and epidermis. It is mostly caused by acne, atopic dermatitis, irritant, allergic and/or contact dermatitis, trauma, psoriasis, lichen planus and drug eruptions. Skin trauma or inflammation can either increase or reduce the production of melanocytes. It is believed that hyperpigmentation is caused by the activity of cytokines, mediators of inflammation and reactive oxygen species.

It is extremely important for dark -skinned people to use different methods to control and reduce the pigmentation. Ideal hypopigmenting agents should have a controlled and selective effect upon melanocytes not entailing any risks of adverse effects. These agents can act on many stages during the melanin production and degradation processes such as: tyrosinase transcription and activationtyrosinase related protein 1 (TRP-1), tyrosinase related protein 2 (TRP-2) and/or peroxidase; capitation and distribution of melanosomes among kerotinocytes; and melanosomic degradation and rotation of “pigmented” keratinocytes.

Moreover, the use of broad spectrum sunscreen effectively prevents the apparition melasma and also cooperates with other topical therapies when treating this affection.

All the aspects mentioned above were taken into consideration when developing MeLine Ethnic Skin in order to guarantee a safe and effective product for the treatment of these affections that can also entail some emotional and psychological repercussions to dark-skinned people.

Generally, these types of lesions appear in skin phototypes I-III, usually in face, forearm, back of the hands and upper torso. It is very important to establish the differential diagnosis between ephelides (freckles), seborrheic keratosis and lentigo maligna.

Solar lentigo is not a condition that requires treatment but its presence means that there is a photodamage and it has an aesthetic repercussion. The ideal treatment for solar lentigo should be cheap, achieve results quickly, it should not obstruct social life and should not present any risks. These affections are particularly difficult to treat when they are localized in the hands as the dermis and epidermis are thinner at this area, circulation is poor, they have not many polysebaceous units and a visible tendency to scar. So, scars could appear when treating these affections in hands.

Innoaesthetics laboratory, always on the cutting-edge, proposes a high safe and effective treatment that combines a depigmenting effect with an epidermolytic activity that favours the improvement of the lesion with no risk of leaving scars.

Many procedures have been proposed for the improvement of this area and most of them were basically surgical methods. Nevertheless, many minimally invasive or non-invasive techniques have been developepd during the last years and have been very usefull for the aesthetical improvement of this area.

Patients are mainly worried about the irregularities and diffences on skin color of the intimate parts. This situation has encouraged the specialists to use some products that are like those designed to treat skin aging and to remove pigmented spots on face. Nevertheless, as the intimate parts have a unique anatomical structure, we have been carrying out methiculous studies to determinate the most appropriate ingredients and the ideal concentrations in order to achieve optimal results without causing any adverse effects.

All these investigations have led us to the development of this new product, INTIMATE, that has proved to be very effective for the improvement of color uniformity and overall skin appearance without causing any adverse effects. MeLine Intimate represents a great option to treat these disorders and its efficacy is backed up by scientific trials. In conclusion, this product achieves very satisfactory results.